Biotin

Vitamins

Biotin

Part of the B-vitamin family; involved in the synthesis of fat, glycogen, and amino acids and enzyme reactions; required for DNA replication; important for healthy hair and nails.

Used therapeutically to strengthen fi ngernails.

Deficiency is rare except in those with hereditary disorders of biotin metabolism, liver disease, and during pregnancy (due to increased needs). It can also occur in those who consume raw egg white for prolonged periods (weeks to years) because a protein found in egg white (avidin) binds biotin and prevents its absorption or in those given intravenous feeding without biotin supplementation.

Deficiency symptoms include hair loss; scaly red rash around the eyes, nose, mouth, and genital area; depression; lethargy; hallucination; numbness and tingling of the extremities; and impaired glucose utilization and immune system function.

Drugs that deplete biotin: primidone, carbamazepine, phenobarbital, phentyoin, valproic acid, and antibiotics.

Most people get adequate biotin from diet and/or supplements.

Food Sources : Egg yolk, liver, wheat bran, yeast, oatmeal, soybeans, caulifl ower, mushrooms, and nuts

Adequate Intake : (mcg/day)*
Men = 30
Women = 30
Pregnancy = 30
Lactation = 35

Upper Limit : Not determined

Side Effects : No adverse effects known with food or supplements